|
|
|
Unmet needs in modern vaccinology Adjuvants to improve the immune response. |
|
| The key objective of vaccination is the induction of an effective pathogen-specific immune response that leads to protection against infection and/or disease caused by that pathogen, and that may ultimately result in its eradication from humanity. The concept that the immune response to pathogen antigens can be improved by the addition of certain compounds into the vaccine formulation was demonstrated about one hundred years ago when aluminium salts were introduced ... |
|
|
Inovio Pharmaceuticals Reports Second Quarter 2010 Financial Results. |
|
BLUE BELL, Pa., Aug 16, 2010 (BUSINESS WIRE) --Inovio Pharmaceuticals, Inc. (NYSE AMEX: INO) today reported financial results for the quarter ended June 30, 2010.
Total revenue was $1.1 million and $2.5 million for the three and six months ended June 30, 2010, compared to $2.5 million and $2.9 million for the three and six months ended June 30, 2009, respectively. |
|
|
Prophylactic Efficacy of TcVac2 against Trypanosoma cruzi in Mice. |
|
| Chagas disease is a major health problem in Latin America, and an emerging infectious disease in the US. Previously, we have screened the Trypanosoma cruzi sequence database by a computational/bioinformatics approach, and identified antigens that exhibited the characteristics of vaccine candidates. |
|
|
Prime-boost vaccinations using recombinant flavivirus replicon and vaccinia virus vaccines: an ELISPOT analysis. |
|
| Recombinant Kunjin replicon virus-like particle (VLP), vaccinia virus (rVV) and DNA vaccines were tested in a large series of prime-boost vaccinations using interferon (IFN)γ ELISPOT assays that reflected effector (E), effector memory (EM) and central memory (CM) responses. All vaccine constructs encoded the murine polytope immunogen and responses to four CD8 T-cell epitopes (TYQRTRALV, SYIPSAEKI, YPHFMPTNL and RPQASGVYM) were measured. |
|
|
Immunization of neonatal mice with LAMP/p55 HIV gag DNA elicits robust immune responses that last to adulthood. |
|
| Successful T cell priming in early postnatal life that can generate effective long-lasting responses until adulthood is critical in HIV vaccination strategies because it prevents early sexual initiation and breastfeeding transmission of HIV. A chimeric DNA vaccine encoding p55 HIV gag associated with lysosome-associated membrane protein 1 (LAMP-1; which drives the antigen to the MIIC compartment), has been used to enhance cellular and humoral antigen-specific responses in adult mice and macaques. Herein, we investigated LAMP-1/gag vaccine immunogenicity in the neonatal period in mice and its ability to generate long-lasting effects. |
|
|
Potent Antirheumatic Activity of a New DNA Vaccine Targeted to B7-2/CD28 Costimulatory Signaling Pathway in Autoimmune Arthritis. |
|
| Rheumatoid arthritis is a pro-inflammatory autoimmune disease attributed to failure of both CD4+CD25+ regulatory T (Tr) and CD8+CD28- suppressor T (Ts) cells to control autoreactive CD4+CD28+Th1 (Th1) and autoantibody-producing B cells. Here we show a single intramuscular injection of our novel targeted DNA vaccine encoding Pseudomonas exotoxin A and costimulatory molecule B7-2 without autoantigens in a collagen-induced arthritis model simultaneously increased Tr and Ts cells and selectively decreased autoreactive Th1 cells. |
|
|
Unique Th1/Th2 Phenotypes Induced During Priming and Memory Phases Using IL-12 or IL-28B Vaccine Adjuvants in rhesus macaques. |
|
| Adjuvant compounds are usually included in vaccination in order to bolster total vaccine-specific responses or to tailor an immune response towards a desired endpoint, such as the production of Interferon gamma or an increase in antibody titers. |
|
|
Efficacy of Shanvac-B recombinant DNA hepatitis B vaccine in health care workers of Northern India. |
|
| Health care workers (HCWs) constitute a high-risk population of HBV infection. There are limited data on the efficacy of vaccination in HCWs in India. This study was to evaluate the efficacy of indigenous recombinant hepatitis B vaccine, Shanvac-B, in HCWs. |
|
|
Vaccination of Chickens with DNA Vaccine Encoding Eimeria acervulina 3-1E and Chicken IL-15 Offers Protection. |
|
Vaccination of Chickens with DNA Vaccine Encoding Eimeria acervulina 3-1E and Chicken IL-15 Offers Protection Against Homologous Challenge.
Eimeria acervulina 3-1E antigen gene and mature chicken interleukin 15 (mChIL-15) gene were cloned into expression vector pcDNA3.1(+) in different forms, produced DNA vaccine pcDNA3.1-3-1E, and pcDNA3.1-3-1E-linker-mChIL-15 co-expressing E. acervulina 3-1E gene and mChIL-15 gene, respectively. |
|
|
Genetic immunization: Bacteria as Dna vaccine delivery vehicles. |
|
| The so-called DNA vaccination represents one of the most notable tools under development in the field of vaccinology. The concept of administering the gene coding for any given protective antigen and make responsible vaccinee's own cells to produce the protein appeals as too simple to be true. |
|
|
Cytokine-FC Fusion Genes as Molecular Adjuvants for DNA Vaccines. |
|
| The use of gene constructs for DNA immunization offers several potential advantages over other commonly used vaccine approaches: (1) full-length cDNA provides multiple potential class I and class II epitopes, thus bypassing limitations of MHC restriction; (2) bacterial plasmid DNA contains immunogenic unmethylated CpG motifs (immunostimulatory sequences) that may act as a potent immunological adjuvant; and (3) DNA is relatively simple to purify in large quantities. |
|
|
|
